Recognize Duchenne Muscular Dystrophy Better

Duchenne muscular dystrophy (DMD) is a progressive, progressive, and hereditary muscular dystrophy about boys. The incidence of the disease is relatively rare, only amounted to one of 3500 male births. The disease is passed down through X-linked recessive, and only about men, while women are just as career. In the DMD there is a genetic disorder that lies on the X chromosome, locus Xp21.22-4 which is responsible for the formation of the dystrophin protein. Pathologic changes in dystrophic muscles occur primarily and are not caused by secondary disease due to central nervous system or peripheral nervous disorders.

Distrofin is a very long protein with a molecular weight of 427 kDa2.4, and consists of 3685 acids amino.2 The main cause of degenerative processes in most DMDs due to deletions on the segment of the gene in charge answer to the formation of dystrophin proteins in the membrane muscle cells, resulting in the absence of such proteins
in muscle tissue. 2 Erb2.5 in 1884 for the first time wearing term dystrophia muscularis progressiva. In the year of 1855, Duchenne2.5 provides a more complete description on progressive muscular atrophy in children. Becker 2 describes a muscular dystrophy disease that can derived autosomal recessive, autosomal dominant or X-linked recessive.2,6 Hoffman et al2.5 explains that Dystrophin protein disorders are a major cause of DMD and Becker Muscular Dystrophy (BMD).

DMD can attack everyone of all ages. Although some are first in infants or children, others may not appear until middle age.

The most common symptoms are muscle weakness (frequent falls, walking disturbances, drowsy eyelids), skeletal and muscle disorders. Neurological examination often finds loss of muscle tissue (wasting), muscle contractures, pseudohypertrophy and weakness. Some types of DMD may arise with additional cardiac abnormalities, intellectual impairment and sterility. Here are the symptoms that can be found:

o Progressive muscle weakness
o Impaired balance
o Often falling
o Difficulty walking
o Waddling Gait
o Calf Pain
o Limited range of motion
o Muscle contractures
o Respiratory disorders
o Ptosis
o Gonad atrophy
o Scoliosis
o Some types of MD can attack the heart, causing cardiomyopathy or arttmia

What are my treatment options for muscular dystrophy (muscular dystrophy)?

No known drugs have been found to cure MD disease. The goal of treatment is simply to control the symptoms. The treatments consist of:

Physical therapy
Surgery on the spine or leg (in some cases)
Use of support aids, sticks, walking aids, and wheelchairs can help mobility and reduce dependence on others
Drugs corticosteroids are sometimes prescribed for children with certain MD disease to help them stay as long as possible

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